Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

@inproceedings{Cheung2016PsoriaticTC,
  title={Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a},
  author={Ka Lun Cheung and Rachael Jarrett and Sumithra Subramaniam and Maryam Salimi and Danuta Gutowska-Owsiak and Yi-Ling Chen and Clare S Hardman and Luzheng Xue and Vincenzo Cerundolo and Graham S Ogg},
  booktitle={The Journal of experimental medicine},
  year={2016}
}
Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response. Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen-presenting Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high levels of CD1a, which presents lipid antigens to T cells. In addition, phospholipase A2 (PLA2) is highly expressed in psoriatic lesions and is known to generate neolipid skin antigens for… CONTINUE READING
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