Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.

@article{Lowes2008PsoriasisVL,
  title={Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.},
  author={M. Lowes and T. Kikuchi and J. Fuentes-Duculan and I. Cardinale and Lisa C. Zaba and A. Haider and E. Bowman and J. Krueger},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 5},
  pages={
          1207-11
        }
}
The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel… Expand
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The immunopathology role of Th 17 cells and functions of the related cytokines in the psoriasis is demonstrated to get a better understanding of the inflammatory mechanisms mediated by Th17 cells in this disease. Expand
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  • A. Blauvelt
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 2008
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