Psoriasis patients with basal cell carcinoma have more repair-mediated DNA strand-breaks after UVC damage in lymphocytes than psoriasis patients without basal cell carcinoma.

@article{Mller2000PsoriasisPW,
  title={Psoriasis patients with basal cell carcinoma have more repair-mediated DNA strand-breaks after UVC damage in lymphocytes than psoriasis patients without basal cell carcinoma.},
  author={Peter M{\o}ller and H{\aa}kan Wallin and Marianne Dybdahl and Georg Frentz and Bj{\o}rn A Nex{\o}},
  journal={Cancer letters},
  year={2000},
  volume={151 2},
  pages={
          187-92
        }
}
We have investigated the formation of strand-breaks following UVC irradiation in lymphocytes from psoriasis patients with or without basal cell carcinoma (BCC). Isolated lymphocytes were irradiated with UVC light at a dose of 3.6 J/m(2), and the level of DNA strand-breaks were measured 25 min after the irradiation by the alkaline comet assay. The generation of strand-breaks following UVC irradiation indicates DNA-repair-mediated incisions, as UVC light does not generate strand-breaks per se. We… CONTINUE READING
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