Psoriasis is associated with increased β-defensin genomic copy number

@article{Hollox2007PsoriasisIA,
  title={Psoriasis is associated with increased β-defensin genomic copy number},
  author={Edward J. Hollox and Ulrike Huffmeier and Patrick L.J.M. Zeeuwen and Raquel Palla and Jes{\'u}s Lascorz and Diana Rodijk-Olthuis and Peter van Kerkhof and Heiko Traupe and Gys de Jongh and Martin den Heijer and Andr{\'e} Reis and John A L Armour and Joost Schalkwijk},
  journal={Nature Genetics},
  year={2007},
  volume={40},
  pages={23-25}
}
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis. 

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