Psoriasis: maintenance of an intact monolayer basal cell differentiation compartment in spite of hyperproliferation.

@article{Leigh1985PsoriasisMO,
  title={Psoriasis: maintenance of an intact monolayer basal cell differentiation compartment in spite of hyperproliferation.},
  author={Irene M. Leigh and Karen Pulford and Frans Charles Servatius Ramaekers and E. Birgitte Lane},
  journal={The British journal of dermatology},
  year={1985},
  volume={113 1},
  pages={53-64}
}
Frozen sections of punch biopsies from normal epidermis and psoriatic involved and uninvolved epidermis have been examined immunocytochemically using a panel of anti-keratin monoclonal antibodies with various specificities in the skin. Since psoriasis is thought to involve hyperproliferative expansion of the basal compartment from one to about three cell layers in thickness, the samples were screened with antibodies to intermediate filament determinants associated with basal cells, suprabasal… CONTINUE READING
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