Psoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion

@article{Richard2013PsoriasisCE,
  title={Psoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion},
  author={M-A Richard and Thomas Barnetche and C. Horreau and Emilie Brenaut and Claire Pouplard and S{\'e}lim Aractingi and François Aubin and Bernard Cribier and Pascal Joly and Denis Jullien and Michel Le Ma{\^i}tre and Laurent Misery and J. P. Ortonne and Carle Paul},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2013},
  volume={27}
}
The relationship between psoriasis, chronic inflammation, cardiovascular risk and risk of cancer has long been debated. In addition, it has been suggested that alcohol consumption may be a risk factor for psoriasis onset and severity. 
Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review
Previous epidemiological studies have demonstrated a high prevalence of cardiovascular (CV) risk factors in psoriasis patients, including metabolic syndrome, cigarette smoking, obesity, hypertension,
Risk of cancer in psoriasis: a systematic review and meta‐analysis of epidemiological studies
TLDR
The relationship between psoriasis and increased cancer risk is debated and research is still needed to establish a cause and effect relationship.
Cardiovascular morbidity, risk of cancer and alcohol abuse in psoriasis: systematic literature reviews and expert opinion
  • M. Richard, C. Paul
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2013
TLDR
The study highlights this major role of dermatologists who have to ensure comorbidities are evaluated and appropriately managed in patients with psoriasis, and addresses the formulated questions addressing cardiovascular morbidity and mortality, cancer risk and alcohol abuse in Psoriasis.
Alcohol consumption and psoriasis: a systematic literature review
The association between alcohol consumption and psoriasis has been frequently discussed since the 1980s, but no systematic review has been elaborated on the subject so far.
PSORIASIS AND CANCER: A SYSTEMIC REVIEW
TLDR
A small increased risk of some solid cancers in psoriasis is shown, especially those linked to alcohol drinking and cigarette smoking and a higher risk of non-melanoma skin cancers is shown.
Evidence‐based recommendations on the role of dermatologists in the diagnosis and management of psoriatic arthritis: systematic review and expert opinion
TLDR
Psoriatic arthritis (PsA) can develop at any time during the course of psoriasis, and patients should be aware of the risk of infection and seek medical treatment immediately.
Cohort study of malignancies and hospitalized infectious events in treated and untreated patients with psoriasis and a general population in the United States
TLDR
Some psoriasis treatments may increase the risk of hospitalized infectious events (HIEs) and be associated with risk of malignancy.
Impact of smoking on psoriasis risk and treatment efficacy: a meta-analysis
TLDR
Smoking increases psoriasis risk and negatively impacts the benefits of biologic agents, however, the number of reports is limited and more studies are needed to confirm the effects of smoking and smoking cessation on therapeutic response in patients with Psoriasis.
Addiction: an underestimated problem in psoriasis health care
Psoriasis is a disease of enormous socio‐economic impact. Despite approval of numerous highly efficient and costly therapies, a minor proportion of severely affected patients actually receives
Psoriasis and cardiovascular disorders: association or epiphenomenon? Meta-analysis of observational studies
TLDR
The present study supports a significant association between psoriasis and incidence of major adverse cardiovascular events and suggests that hypertension is a highly associative condition in Psoriasis.
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References

SHOWING 1-10 OF 46 REFERENCES
Cardiovascular morbidity and mortality in psoriasis and psoriatic arthritis: a systematic literature review
Previous epidemiological studies have demonstrated a high prevalence of cardiovascular (CV) risk factors in psoriasis patients, including metabolic syndrome, cigarette smoking, obesity, hypertension,
Risk of cancer in psoriasis: a systematic review and meta‐analysis of epidemiological studies
TLDR
The relationship between psoriasis and increased cancer risk is debated and research is still needed to establish a cause and effect relationship.
Psoriasis and risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case–control analysis
TLDR
This data indicates that pre-existing Psoriasis patients with high levels of inflammation may be at increased risk for cardiovascular diseases in patients with early psoriasis, but data on this risk is scarce.
Cardiovascular risk factors in patients with plaque psoriasis: a systematic review of epidemiological studies
  • S. Prey, C. Paul, J. Ortonne
  • Medicine, Biology
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2010
TLDR
The aim of this systemic review was to evaluate the risk of diabetes, hypertension, dyslipidaemia and obesity in adults with plaque psoriasis, and the relationship between therisk of cardiovascular risk factors and Psoriasis severity.
Alcohol consumption and psoriasis: a systematic literature review
The association between alcohol consumption and psoriasis has been frequently discussed since the 1980s, but no systematic review has been elaborated on the subject so far.
Cause‐specific mortality in patients with severe psoriasis: a population‐based cohort study in the U.K.
Background  Severe psoriasis is associated with excess mortality and increased risk of cardiovascular death. Population‐based data evaluating cause‐specific mortality in patients with psoriasis are
Evidence‐based recommendations on conventional systemic treatments in psoriasis: systematic review and expert opinion of a panel of dermatologists
TLDR
There is a high level of heterogeneity regarding the practical use of conventional systemic treatment in psoriasis and the need to select patients suitable for this type of treatment based on their prior Psoriasis history.
Evidence‐based recommendations to assess psoriasis severity: systematic literature review and expert opinion of a panel of dermatologists
TLDR
This study highlights the need to understand more fully the role of immune checkpoints in the development of psoriasis and the role they play in the physical and mental health of patients.
Assessment of risk of psoriatic arthritis in patients with plaque psoriasis: a systematic review of the literature
  • S. Prey, C. Paul, J. Ortonne
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2010
Objective  The aim of this study was to determine the prevalence of psoriatic arthritis (PsA) in the patients with plaque psoriasis and to give recommendation for the diagnosis of PsA for
Survival in cancer patients hospitalized for psoriasis: a population‐based cohort study in Sweden
TLDR
This data indicates that treatment with corticosteroids after psoriasis increases the risk of cancer in patients with previously diagnosed psorosis, but the prognosis in these patients is still unclear.
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