Psoralens and UV-A and UV-B twice weekly for the treatment of psoriasis.


In an effort to determine if combination phototherapy (psoralens and UV-A [PUVA]) [PUVA-UV-B]) administered twice weekly provides a substantial advantage over therapy with PUVA alone, we investigated twice-weekly PUVA-UV-B therapy for the treatment of psoriasis. In a bilateral comparison study of 11 patients, we found that seven cases of psoriasis cleared in the same number of treatments with PUVA-UV-B or PUVA, but in four cases the PUVA-UV-B treated side cleared significantly more rapidly. In a study of these 11 split cases, plus ten additional patients treated with PUVA-UV-B twice weekly, this therapy was effective in clearing psoriasis. A bilateral comparison of "aggressive" and "nonaggressive" PUVA and UV-B increments in ten patients suggested that lower doses of PUVA and UV-B may, in the majority of patients, be equally effective. Further study is necessary to define the maximally effective protocol--maximizing clearance yet minimizing UV exposure, acute side effects, and long-term toxic reactions.


Citations per Year

157 Citations

Semantic Scholar estimates that this publication has 157 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Diette1984PsoralensAU, title={Psoralens and UV-A and UV-B twice weekly for the treatment of psoriasis.}, author={Kevin Diette and K Momtaz-T and Robert S Stern and Kenneth A. Arndt and John A . Parrish}, journal={Archives of dermatology}, year={1984}, volume={120 9}, pages={1169-73} }