Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.

@article{Cardone2006PsoralensensitiveMP,
  title={Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.},
  author={Jacqueline Moraes Cardone and Lu{\'i}s Fernando Revers and Roseane M. Machado and Diego Bonatto and Martin Brendel and Jo{\~a}o Antonio P{\^e}gas Henriques},
  journal={DNA repair},
  year={2006},
  volume={5 2},
  pages={163-71}
}
Complementation analysis of the pso9-1 yeast mutant strain sensitive to photoactivated mono- and bifunctional psoralens, UV-light 254 nm, and nitrosoguanidine, with pso1 to pso8 mutants, confirmed that it contains a novel pso mutation. Molecular cloning via the reverse genetics complementation approach using a yeast genomic library suggested pso9-1 to be a mutant allele of the DNA damage checkpoint control gene MEC3. Non-complementation of several sensitivity phenotypes in pso9-1/mec3Delta… CONTINUE READING

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