Psoralen adducts induced by triplex-forming oligonucleotides are refractory to repair in HeLa cells.

Abstract

The use of triple helix-forming oligonucleotides constitutes an attractive strategy to regulate gene expression by inhibition of transcription. Psoralen-oligonucleotide conjugates form, upon irradiation, covalent triplexes and thereby modify the specific target sequence. The processing of such photoproducts on the promoter of the gene coding for the… (More)

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@article{Guieysse2000PsoralenAI, title={Psoralen adducts induced by triplex-forming oligonucleotides are refractory to repair in HeLa cells.}, author={A L Guieysse and Dani{\`e}le Praseuth and Carine Giovannangeli and Ulysse Asseline and Claude H{\'e}l{\`e}ne}, journal={Journal of molecular biology}, year={2000}, volume={296 2}, pages={373-83} }