Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action

  title={Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action},
  author={F. Vollenweider and M. F. Vollenweider-Scherpenhuyzen and A. B{\"a}bler and H. Vogel and D. Hell},
  • F. Vollenweider, M. F. Vollenweider-Scherpenhuyzen, +2 authors D. Hell
  • Published 1998
  • Psychology, Medicine
  • NeuroReport
  • PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that… CONTINUE READING
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