Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action

@article{Vollenweider1998PsilocybinIS,
  title={Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action},
  author={Franz X. Vollenweider and M F Vollenweider-Scherpenhuyzen and Andreas B{\"a}bler and H. Vogel and Daniel Hell},
  journal={NeuroReport},
  year={1998},
  volume={9},
  pages={3897–3902}
}
PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that… Expand
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Recent advances in understanding of the crosstalk between these two receptors, as well as their implication in schizophrenia and antipsychotic drug action are reviewed. Expand
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Results on the receptor, signalling and circuit mechanisms underlying the response to psychedelic and antipsychotic drugs might lead to unification of the serotonin and glutamate neurochemical hypotheses of schizophrenia. Expand
Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.
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Recent advances in understanding hallucinogen drug action are reviewed through characterization of structure, neuroanatomical location, and function of the 5-HT2A receptor. Expand
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The electrophysiology of 5-HT2A receptors in the prefrontal cortex and their relevance for normal brain function and for hallucinogen and atypical antipsychotic drug actions are explored. Expand
Serotonin and serotonin receptors in hallucinogen action
Abstract Hallucinogens (psychedelics) are substances that induce profound changes in perception and cognition. The closely related 3,4-methylenedioxymethamphetamine (MDMA) produces euphoria and a… Expand
Animal Models and Hallucinogenic Drugs
TLDR
Recent advances in the understanding of the molecular mechanism of action of hallucinogenic drugs, as well as findings obtained in animal models are summarized. Expand
Animal models of serotonergic psychedelics.
TLDR
The behavioral effects induced by psychedelic drugs in rodent models are reviewed, the translational potential of these findings are discussed, and areas where further research is needed to better understand the molecular mechanisms and neuronal circuits underlying their neuropsychological effects are defined. Expand
Serotonin-Related Psychedelic Drugs
Serotonergic hallucinogens include the prototypical compounds such as mescaline, psilocybin, and LSD, representing the chemical classes of phenethylamines, tryptamines, and ergolines. Known as… Expand
Alterations of serotonin transmission in schizophrenia.
  • A. Abi-Dargham
  • Psychology, Medicine
  • International review of neurobiology
  • 2007
TLDR
A modulatory role of serotonergic agents on dopamine transmission in schizophrenia is reinforced, which may contribute to the therapeutic effects of atypical antipsychotics. Expand
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