Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action

@article{Vollenweider1998PsilocybinIS,
  title={Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action},
  author={F. Vollenweider and M. F. Vollenweider-Scherpenhuyzen and A. B{\"a}bler and H. Vogel and D. Hell},
  journal={NeuroReport},
  year={1998},
  volume={9},
  pages={3897–3902}
}
  • F. Vollenweider, M. F. Vollenweider-Scherpenhuyzen, +2 authors D. Hell
  • Published 1998
  • Psychology, Medicine
  • NeuroReport
  • PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that… CONTINUE READING
    504 Citations
    Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.
    • 18
    • Highly Influenced
    • PDF
    Psychedelics and schizophrenia
    • 130
    Animal models of serotonergic psychedelics.
    • 79
    Alterations of serotonin transmission in schizophrenia.
    • A. Abi-Dargham
    • Psychology, Medicine
    • International review of neurobiology
    • 2007
    • 77

    References

    SHOWING 1-10 OF 13 REFERENCES
    The mechanism of action of novel antipsychotic drugs.
    • H. Meltzer
    • Psychology, Medicine
    • Schizophrenia bulletin
    • 1991
    • 370
    • PDF
    LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.
    • 123
    Dreams, hallucinogenic drug states, and schizophrenia: a psychological and biological comparison.
    • L. Fischman
    • Psychology, Medicine
    • Schizophrenia bulletin
    • 1983
    • 83
    • PDF
    Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
    • 185
    "Psychedelic" experiences in acute psychoses.
    • 162
    Schizophrenics show spatial working memory deficits.
    • 924
    • PDF
    5-hydroxytryptamine receptor interactions of D-lysergic acid diethylamide.In: Pletscher A and Ladewig D, eds. 50 Years of LSD
    • Current Status and Perspectives of Hallucinogens. New York: Parthenon Publishing,
    • 1994