Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action

  title={Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action},
  author={Franz X. Vollenweider and M F Vollenweider-Scherpenhuyzen and Andreas B{\"a}bler and H. Vogel and Daniel Hell},
PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that… 

Crosstalk Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment

Recent advances in understanding of the crosstalk between these two receptors, as well as their implication in schizophrenia and antipsychotic drug action are reviewed.

Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.

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Psychedelics and schizophrenia

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Animal Models and Hallucinogenic Drugs

Recent advances in the understanding of the molecular mechanism of action of hallucinogenic drugs, as well as findings obtained in animal models are summarized.

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The behavioral effects induced by psychedelic drugs in rodent models are reviewed, the translational potential of these findings are discussed, and areas where further research is needed to better understand the molecular mechanisms and neuronal circuits underlying their neuropsychological effects are defined.

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It is concluded that LSD and DOI, a phenethylamine hallucinogen, act as highly potent partial agonists at cortical 5-HT2A receptors at rat piriform cortical interneurons.

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Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

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5 - hydroxytryptamine receptor interactions of D - lysergic acid diethylamide