Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action
@article{Vollenweider1998PsilocybinIS,
title={Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action},
author={Franz X. Vollenweider and M F Vollenweider-Scherpenhuyzen and Andreas B{\"a}bler and H. Vogel and Daniel Hell},
journal={NeuroReport},
year={1998},
volume={9},
pages={3897–3902}
}PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that…
657 Citations
Crosstalk Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment
- Psychology, Medicine
- 2018
Recent advances in understanding of the crosstalk between these two receptors, as well as their implication in schizophrenia and antipsychotic drug action are reviewed.
Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.
- Biology, PsychologyCurrent topics in behavioral neurosciences
- 2018
Recent advances in understanding hallucinogen drug action are reviewed through characterization of structure, neuroanatomical location, and function of the 5-HT2A receptor.
Serotonergic Hallucinogens and Emerging Targets for Addiction
- Biology, Psychology
- 2012
Given that SHs increase extracellular glutamate levels and activity in the prefrontal– limbic circuitry, it is possible that a normalization in functional connectivity in this network through a glutamate-dependent neuroplastic adaptation could produce an anti-addictive effect.
Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions
- Psychology, Biology
- 2006
The electrophysiology of 5-HT2A receptors in the prefrontal cortex and their relevance for normal brain function and for hallucinogen and atypical antipsychotic drug actions are explored.
Serotonin and serotonin receptors in hallucinogen action
- Psychology, BiologyHandbook of Behavioral Neuroscience
- 2020
Animal Models and Hallucinogenic Drugs
- Psychology, Biology
- 2013
Recent advances in the understanding of the molecular mechanism of action of hallucinogenic drugs, as well as findings obtained in animal models are summarized.
Animal models of serotonergic psychedelics.
- Psychology, BiologyACS chemical neuroscience
- 2013
The behavioral effects induced by psychedelic drugs in rodent models are reviewed, the translational potential of these findings are discussed, and areas where further research is needed to better understand the molecular mechanisms and neuronal circuits underlying their neuropsychological effects are defined.
Alterations of serotonin transmission in schizophrenia.
- Psychology, MedicineInternational review of neurobiology
- 2007
References
SHOWING 1-10 OF 11 REFERENCES
The mechanism of action of novel antipsychotic drugs.
- Psychology, BiologySchizophrenia bulletin
- 1991
The chief evidence for this position is that clozapine (CLOZ) does not differ from typical antipsychotic drugs in these regards but is more effective than typical neuroleptic drugs.
LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1996
It is concluded that LSD and DOI, a phenethylamine hallucinogen, act as highly potent partial agonists at cortical 5-HT2A receptors at rat piriform cortical interneurons.
Dreams, hallucinogenic drug states, and schizophrenia: a psychological and biological comparison.
- Psychology, MedicineSchizophrenia bulletin
- 1983
In the present article, certain fundamental areas of convergence between the three states are described and current neurophysiological theories of dream and hallucinogenic drug states are presented, with emphasis upon serotonin neurotransmission.
Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
- Psychology, MedicineBiological Psychiatry
- 1997
DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT(2A) and not by 5-HT(2C) receptors.
- Psychology, Biology
- 1995
The view that MDL 100,907 may be a novel atypical antipsychotic is supported and the hypothesis that the 5-HT(2A) receptor is involved in the modulation of sensorimotor gating is supported.
Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 1988
LSD partially antagonized the effect of 5-HT in the choroid plexus, consistent with a partial agonist effect at the 5- HT-1c receptor in this tissue.
The dopamine receptor: differential binding of d-LSD and related agents to agonist and antagonist states.
- Biology, PsychologyLife sciences
- 1975
"Psychedelic" experiences in acute psychoses.
- PsychologyArchives of general psychiatry
- 1966
The disease which thus evokes these new and wonderful talents and operations of the mind may be compared to an earthquake which, by convulsing the upper strata of our globe, throws upon its surface…
Schizophrenics show spatial working memory deficits.
- Psychology, BiologyArchives of general psychiatry
- 1992
It is demonstrated that schizophrenics are impaired on spatial delayed-response tasks, analogous to those that have been used to assess the working memory function of the dorsolateral prefrontal cortex in rhesus monkeys, and that this deficit is modality independent.