Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations

@article{Kometer2015PsilocybininducedSE,
  title={Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations},
  author={Michael W Kometer and Thomas Pokorny and Erich Seifritz and Franz X. Volleinweider},
  journal={Psychopharmacology},
  year={2015},
  volume={232},
  pages={3663-3676}
}
RationaleDuring the last years, considerable progress has been made toward understanding the neuronal basis of consciousness by using sophisticated behavioral tasks, brain-imaging techniques, and various psychoactive drugs. Nevertheless, the neuronal mechanisms underlying some of the most intriguing states of consciousness, including spiritual experiences, remain unknown.ObjectivesTo elucidate state of consciousness-related neuronal mechanisms, human subjects were given psilocybin, a naturally… 

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References

SHOWING 1-10 OF 101 REFERENCES
Broadband Cortical Desynchronization Underlies the Human Psychedelic State
TLDR
The findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells.
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
TLDR
Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
TLDR
When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences, and the ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
TLDR
When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences that, at 14-month follow-up, were considered by volunteers to be among the most personally meaningful and spiritually significant of their lives.
Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers.
TLDR
The q-EEG profile supports the role of 5-HT2 and dopamine D2-receptor agonism in mediating the effects of ayahuasca on the central nervous system, and shows a time pattern which closely paralleled that of previously reported subjective effects.
Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on α Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations
TLDR
It is found that psilocybin strongly decreased prestimulus parieto-occipital α power values, thus precluding a subsequent stimulus-induced α power decrease, and the observed reduction of N170 visual-evoked potentials may be a key mechanism underlying 5-HT2A receptor-mediated visual hallucinations.
Intrinsic Brain Activity in Altered States of Consciousness
TLDR
Results suggest that slow coherent spontaneous BOLD fluctuations cannot be exclusively a reflection of conscious mental activity, but may reflect default brain connectivity shaping brain areas of most likely interactions in a way that transcends levels of consciousness, and whose functional significance remains largely in the dark.
Use of the Classic Hallucinogen Psilocybin for Treatment of Existential Distress Associated with Cancer
This chapter reviews the potential of a treatment approach that uses psilocybin, a novel psychoactive drug, to ameliorate the psychospiritual distress and demoralization that often accompany a
...
1
2
3
4
5
...