Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

@inproceedings{CarhartHarris2017PsilocybinFT,
  title={Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms},
  author={Robin L. Carhart-Harris and Leor Roseman and Mark Bolstridge and Lysia Demetriou and Justine Nienke Pannekoek and Matthew B. Wall and Mark W. Tanner and Mendel Kaelen and John E McGonigle and Kevin Murphy and Robert Leech and Helen Valerie Curran and David J Nutt},
  booktitle={Scientific Reports},
  year={2017}
}
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of… CONTINUE READING

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