Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

@article{Griffiths2006PsilocybinCO,
  title={Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance},
  author={R. R. Griffiths and Waldo Richards and Ud McCann and Robert Jesse},
  journal={Psychopharmacology},
  year={2006},
  volume={187},
  pages={268-283}
}
RationaleAlthough psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects.ObjectivesThis double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions.Materials and methodsThe participants were hallucinogen-naïve adults reporting regular participation in religious or spiritual activities… 
Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
TLDR
When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences that, at 14-month follow-up, were considered by volunteers to be among the most personally meaningful and spiritually significant of their lives.
spiritual significance 14 months later Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and
Psilocybin has been used for centuries for religious purposes; however, little is known scientifically about its long-term effects. We previously reported the effects of a double-blind study
Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
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Under supportive conditions, 20 and 30 mg/70 kg psilocybin occasioned mystical-type experiences having persisting positive effects on attitudes, mood, and behavior.
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Psychedelic drugs such as psilocybin have shown substantial promise for the treatment of several psychiatric conditions including mood and addictive disorders. They also have the remarkable property
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Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors
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Both high-dose psilocybin groups showed large significant positive changes on longitudinal measures of interpersonal closeness, gratitude, life meaning/purpose, forgiveness, death transcendence, daily spiritual experiences, religious faith and coping, and community observer ratings.
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The present results indicate similarities as well as differences between the subjective effects of S. divinorum and other hallucinogenic states beyond serotonergic mechanisms as a selective kappa opioid receptor agonist.
Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction.
TLDR
Smoking cessation outcomes were significantly correlated with measures of mystical experience on session days, as well as retrospective ratings of personal meaning and spiritual significance of psilocybin sessions, suggesting a mediating role of Mystical experience in psychedelic-facilitated addiction treatment.
Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
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A single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data, providing a strong rationale for controlled trials with larger samples to investigate efficacy and mechanisms.
The subjective experience of acute, experimentally-induced Salvia divinorum inebriation
TLDR
This study examined the overall psychological effects of inebriation facilitated by the naturally-occurring plant hallucinogen Salvia divinorum using a double-blind, randomized, placebo-controlled trial to provide an initial framework for greater understanding of the subjective effects of Salviadivinorum, an emerging drug of abuse.
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