Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

@article{Bogenschutz2015PsilocybinassistedTF,
  title={Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study},
  author={Michael P. Bogenschutz and Alyssa A. Forcehimes and Jessica A Pommy and Claire E. Wilcox and Pcr Barbosa and Rick J. Strassman},
  journal={Journal of Psychopharmacology},
  year={2015},
  volume={29},
  pages={289 - 299}
}
Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects of psilocybin in various populations, there have been no studies on the efficacy of psilocybin for alcohol dependence. We conducted a single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data. Ten… 
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The view that the quality of the acute psychedelic experience is a key mediator of long-term changes in mental health is bolstered, as data from a clinical trial assessing psilocybin for treatment-resistant depression confirmed this.
A potential role for psilocybin in the treatment of obsessive-compulsive disorder
  • E. Jacobs
  • Medicine
    Journal of Psychedelic Studies
  • 2020
TLDR
Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.
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