Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA.

@article{Chen2000PseudouridineS3,
  title={Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA.},
  author={J K Chen and Jeffrey R. Patton},
  journal={Biochemistry},
  year={2000},
  volume={39 41},
  pages={12723-30}
}
A cDNA encoding mouse pseudouridine synthase 3 (mPus3p) has been cloned. The predicted protein has 34% identity with yeast pseudouridine synthase 3 (Pus3), an enzyme known to form pseudouridine at positions 38 and 39 in yeast tRNA. The cDNA is 1.7 kb, and when used as a probe on a Northern blot of total RNA from mouse tissues or cells in culture, a band at 1.8 kb was observed. The open reading frame codes for a protein of 481 amino acids with a predicted molecular mass of 55 552 Da. When mPus3p… CONTINUE READING
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