Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction

@inproceedings{Parker2013PseudotypingTA,
  title={Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction},
  author={Alan L Parker and Katie M. White and Christopher A. Lavery and Jerome Custers and Simon N Waddington and Andrew H. Baker},
  booktitle={Gene Therapy},
  year={2013}
}
Ex vivo gene therapy during coronary artery bypass grafting (CABG) holds great potential to prevent excessive smooth muscle cell (SMC) proliferation, neointima formation and graft failure. The most successful preclinical strategies to date have utilised vectors based on the species C adenovirus, Ad5, which engages the Coxsackie and Adenovirus receptor (CAR) as its primary attachment receptor. Profiling receptors on human SMCs demonstrated the absence of CAR but substantial expression of the… CONTINUE READING
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vein graft neointima formation by ex vivo TIMP-3 gene therapy

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