Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of vif for optimal infectivity: functional difference between Vif and Nef.

@article{Akari1999PseudotypingHI,
  title={Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of vif for optimal infectivity: functional difference between Vif and Nef.},
  author={Hirofumi Akari and Takehiko Uchiyama and Tatsuo Fukumori and Shinsuke Iida and A. Hajime Koyama and Akio Adachi},
  journal={The Journal of general virology},
  year={1999},
  volume={80 ( Pt 11)},
  pages={2945-9}
}
The functions of Vif and Nef in human immunodeficiency virus type 1 (HIV-1) infection have some similarities: Vif- and Nef-dependent enhancement of HIV-1 replication is cell type-specific, and defective mutations in these genes result in restricted proviral DNA synthesis in infected cells. It has recently been shown that pseudotyping HIV-1 by the envelope glycoprotein of vesicular stomatitis virus (VSV-G) targets HIV-1 entry to an endocytic pathway and suppresses the requirement of Nef for… CONTINUE READING

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