Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity.

@article{Powell2012PseudotypedIA,
  title={Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity.},
  author={Timothy J. Powell and Jonathan D. Silk and Jane L. Sharps and Ervin Fodor and Alain Townsend},
  journal={Journal of virology},
  year={2012},
  volume={86 24},
  pages={13397-406}
}
There is a need for vaccines that can protect broadly across all influenza A strains. We have produced a pseudotyped influenza virus based on suppression of the A/PR/8/34 hemagglutinin signal sequence (S-FLU) that can infect cells and express the viral core proteins and neuraminidase but cannot replicate. We show that when given by inhalation to mice, S-FLU is nonpathogenic but generates a vigorous T cell response in the lung associated with markedly reduced viral titers and weight loss after… CONTINUE READING

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