Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.

  title={Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation.},
  author={Chun Zeng and Francesca Mulas and Yinghui Sui and Tiffany Guan and Nathanael Miller and Yuliang Tan and Fenfen Liu and Wen Jun Jin and Andrea C. Carrano and Mark O. Huising and Orian S Shirihai and Gene W. Yeo and Maike Sander},
  journal={Cell metabolism},
  volume={25 5},
Pancreatic β cell mass for appropriate blood glucose control is established during early postnatal life. β cell proliferative capacity declines postnatally, but the extrinsic cues and intracellular signals that cause this decline remain unknown. To obtain a high-resolution map of β cell transcriptome dynamics after birth, we generated single-cell RNA-seq data of β cells from multiple postnatal time points and ordered cells based on transcriptional similarity using a new analytical tool. This… CONTINUE READING
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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

  • C. Trapnell, D. Cacchiarelli, +7 authors J. L. Rinn
  • Nat. Biotechnol
  • 2014
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