Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat.

@article{Husak2000PseudorabiesVM,
  title={Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat.},
  author={Paul J. Husak and Timothy T. Kuo and Lynn W Enquist},
  journal={Journal of virology},
  year={2000},
  volume={74 23},
  pages={10975-83}
}
The membrane proteins gI and gE of Pseudorabies virus (PRV) are required for viral invasion and spread through some neural pathways of the rodent central nervous system. Following infection of the rat retina with wild-type PRV, virus replicates in retinal ganglion neurons and anterogradely spreads to infect all visual centers in the brain. By contrast, gI and gE null mutants do not infect a specific subset of the visual centers, e.g., the superior colliculus and the dorsal lateral geniculate… CONTINUE READING

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