Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2.

@article{Zaas2005PseudomonasIO,
  title={Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2.},
  author={David William Zaas and Mathew J Duncan and Guojie Li and Jo Rae Wright and Soman N. Abraham},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4864-72}
}
Pseudomonas aeruginosa is a major cause of pneumonia in patients with cystic fibrosis and other immuncompromising conditions. Here we showed that P. aeruginosa invades type I pneumocytes via a lipid raft-mediated mechanism. P. aeruginosa invasion of rat primary type I-like pneumocytes as well as a murine lung epithelial cell line 12 (MLE-12) is inhibited by drugs that remove membrane cholesterol and disrupt lipid rafts. Confocal microscopy demonstrated co-localization of intracellular P… CONTINUE READING

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