Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1β expression through hematopoietic NOD2 signaling.

@article{Alnabhani2015PseudomonasFA,
  title={Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1β expression through hematopoietic NOD2 signaling.},
  author={Ziad Alnabhani and Nicolas Montcuquet and Kelly Biaggini and Monique Dussaillant and Maryline Roy and Eric Ogier-Denis and Amar Madi and Abdelhak Jallane and Marc Feuilloley and Juliette Hugot and Nathalie Connil and Fr{\'e}d{\'e}rick Barreau},
  journal={Inflammatory bowel diseases},
  year={2015},
  volume={21 3},
  pages={
          543-55
        }
}
BACKGROUND Ileal Crohn's disease is related to NOD2 mutations and to a gut barrier dysfunction. Pseudomonas fluorescens has also been associated with ileal Crohn's disease. The aim of this study was to determine the impact of P. fluorescens on the paracellular permeability in ileum and Peyer's patches. METHODS To explore this question, in vivo and ex vivo experiments were performed in wild-type, Nod2, Nod2, and IL-1R mice together with in vitro analyses using the Caco-2 (epithelial) and the… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Similar Papers

Loading similar papers…