Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection.

  title={Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection.},
  author={H. P. Zhu and R. M. I. Bandara and Tim Conibear and Sophy J Thuruthyil and Scott A Rice and Staffan J. Kjelleberg and Michael C Givskov and Mark Willcox},
  journal={Investigative ophthalmology & visual science},
  volume={45 6},
PURPOSE To understand the importance of Pseudomonas aeruginosa quorum-sensing systems in the development of corneal infection, the genotypic characteristics and pathogenesis of seven ocular isolates with low-protease and acyl homoserine lactone (AHL) activity and quorum-sensing mutants of PAO1 deficient in lasI, lasR, or rhlR were investigated in the study. METHODS The possession of the quorum-sensing genes lasI, lasR, rhlI, rhlR, and the quorum-sensing controlled genes lasB, aprA, and rhlAB… CONTINUE READING
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