Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

@inproceedings{Borlee2010PseudomonasAU,
  title={Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix},
  author={Bradley R Borlee and Aaron David Goldman and Keiji Murakami and Ram Samudrala and Daniel J Wozniak and Matthew R. Parsek},
  booktitle={Molecular microbiology},
  year={2010}
}
Pseudomonas aeruginosa, the principal pathogen of cystic fibrosis patients, forms antibiotic-resistant biofilms promoting chronic colonization of the airways. The extracellular (EPS) matrix is a crucial component of biofilms that provides the community multiple benefits. Recent work suggests that the secondary messenger, cyclic-di-GMP, promotes biofilm formation. An analysis of factors specifically expressed in P. aeruginosa under conditions of elevated c-di-GMP, revealed functions involved in… CONTINUE READING
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