Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis.

@article{Erickson2002PseudomonasAQ,
  title={Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis.},
  author={David L. Erickson and Ryan V W Endersby and Amanda J. Kirkham and Kent Jason Stuber and Dolina D. Vollman and Harvey R Rabin and Ian Mitchell and Douglas Gordon Storey},
  journal={Infection and immunity},
  year={2002},
  volume={70 4},
  pages={1783-90}
}
Individuals with cystic fibrosis (CF) are commonly colonized with Pseudomonas aeruginosa. The chronic infections caused by P. aeruginosa are punctuated by acute exacerbations of the lung disease, which lead to significant morbidity and mortality. As regulators of virulence determinants, P. aeruginosa quorum-sensing systems may be active in the chronic lung infections associated with CF. We have examined the levels of autoinducer molecules and transcript accumulation from the bacterial… CONTINUE READING

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