Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization.

@article{Kong2006PseudomonasAP,
  title={Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization.},
  author={Fansheng Kong and Lisa Young and Yi Chen and Huimin Ran and Melanie F Meyers and Patricia Joseph and Y Cho and Daniel J Hassett and Gee W Lau},
  journal={Cellular microbiology},
  year={2006},
  volume={8 7},
  pages={
          1121-33
        }
}
Pseudomonas aeruginosa (PA) is a major pathogen causing morbidity and ultimately mortality in patients afflicted with cystic fibrosis (CF) lung disease. One important virulence factor, pyocyanin (PCN), is a blue, redox-active compound that is secreted in such copious amounts by PA in the CF lungs that it determines the colour of expectorated sputum. In this study, we discovered that physiological concentrations of PCN inactivate the airway epithelial vacuolar ATPase, resulting in reduced… CONTINUE READING
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