Pseudomonas aeruginosa keratitis in IL-6-deficient mice.

  title={Pseudomonas aeruginosa keratitis in IL-6-deficient mice.},
  author={Nerida Cole and Shisan J. Bao and Fiona Jane Stapleton and Archana N. Thakur and Alan J. Husband and Kenneth W. Beagley and Mark Willcox},
  journal={International archives of allergy and immunology},
  volume={130 2},
BACKGROUND Pseudomonas aeruginosa infection is one of the most destructive diseases of the eye. The host response to this infection is critical to the outcome. Interleukin-6 (IL-6) is implicated in this response; however, the mechanisms by which IL-6 contributes to the host defences in corneal infection remain unclear. Using IL-6-/- mice, we have explored the role of IL-6 in P. aeruginosa keratitis. METHODS The eyes of IL-6 gene knockout and wild-type mice were challenged topically with P… CONTINUE READING

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