Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor.

  title={Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor.},
  author={Kazuhiro Kohri and Iris F. Ueki and Jae Jeong Shim and P R Burgel and Yu Mi Oh and Dominic Cheng-Wei Tam and Trang P Dao-Pick and Jay A. Nadel},
  journal={The European respiratory journal},
  volume={20 5},
Hypersecretory disease associated with Pseudomonas aeruginosa (PA) infections is characterised by increased goblet cells and increased mucin production. Recently, an epidermal growth factor receptor (EGFR) signalling cascade was shown to be a common pathway through which many stimuli induce mucin MUC5AC expression in airways by differentiation to a goblet cell phenotype. This study looked at whether PA products induce EGFR expression and activation and thus result in mucin MUC5AC production… CONTINUE READING


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