Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

@inproceedings{Plas2016PseudomonasAE,
  title={Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses},
  author={Mariena J. A. van der Plas and Ravi K V Bhongir and Sven Kjellstr{\"o}m and Helena Siller and Gopinath Kasetty and Matthias M{\"o}rgelin and Artur Schmidtchen},
  booktitle={Nature communications},
  year={2016}
}
Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 22 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.

Proceedings of the National Academy of Sciences of the United States of America • 2017

Biofilms and host response - helpful or harmful.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica • 2017

Similar Papers

Loading similar papers…