Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

Abstract

The lungs of cystic fibrosis (CF) patients are commonly colonized with Pseudomonas aeruginosa biofilms. Chronic endobronchial P. aeruginosa infections are impossible to eradicate with antibiotics, but intensive suppressive antibiotic therapy is essential to maintain the lung function of CF patients. The treatment often includes beta-lactam antibiotics. How… (More)

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Cite this paper

@article{Bagge2004PseudomonasAB, title={Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.}, author={Niels Bagge and Martin Schuster and M. D. E. Hentzer and Oana Ciofu and Michael C Givskov and Everett Peter Greenberg and Niels H\oiby}, journal={Antimicrobial agents and chemotherapy}, year={2004}, volume={48 4}, pages={1175-87} }