Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells.

@article{Williams2004PseudomonasAA,
  title={Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells.},
  author={Simon C. Williams and Erin Patterson and Nancy L. Carty and John A. Griswold and Abdul N Hamood and Kendra P. Rumbaugh},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 8},
  pages={2281-7}
}
Quorum sensing (QS) is a cell density-dependent signaling mechanism used by many bacteria to control gene expression. Several recent reports indicate that the signaling molecules (autoinducers) that mediate QS in Pseudomonas aeruginosa may also modulate gene expression in host cells; however, the mechanisms are largely unknown. Here we show that two P. aeruginosa autoinducers, N-3-oxododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can both enter eukaryotic cells and activate… CONTINUE READING

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