Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.

@article{Fothergill2014PseudomonasAA,
  title={Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs.},
  author={Joanne L Fothergill and Daniel R Neill and Nick J. Loman and Craig Winstanley and Aras Kadioglu},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={
          4780
        }
}
Chronic bacterial infections are a key feature of a variety of lung conditions. The opportunistic bacterium, Pseudomonas aeruginosa, is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the paranasal sinuses and nasopharynx) play an important role as a silent reservoir of bacteria. Over time, P. aeruginosa can adapt to its niche, leading to increased resistance in the face of the immune system… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients

J Jeukens
  • PLoS ONE 9,
  • 2014

Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization.

  • Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
  • 2013