Pseudokinases-remnants of evolution or key allosteric regulators?

  title={Pseudokinases-remnants of evolution or key allosteric regulators?},
  author={Elton Zeqiraj and Daan M F van Aalten},
  booktitle={Current opinion in structural biology},
Protein kinases provide a platform for the integration of signal transduction networks. A key feature of transmitting these cellular signals is the ability of protein kinases to activate one another by phosphorylation. A number of kinases are predicted by sequence homology to be incapable of phosphoryl group transfer due to degradation of their catalytic motifs. These are termed pseudokinases and because of the assumed lack of phosphoryltransfer activity their biological role in cellular… CONTINUE READING
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