Pseudohypoparathyroidism type Ia. Albright hereditary osteodystrophy: a model for research on G protein-coupled receptors and genomic imprinting.

@article{Simon2000PseudohypoparathyroidismTI,
  title={Pseudohypoparathyroidism type Ia. Albright hereditary osteodystrophy: a model for research on G protein-coupled receptors and genomic imprinting.},
  author={Anna Simon and H. P. F. Koppeschaar and Janine F M Roijers and Jo W. M. H{\"o}ppener and Cornells J. M. Lips},
  journal={The Netherlands journal of medicine},
  year={2000},
  volume={56 3},
  pages={100-9}
}
Pseudohypoparathyroidism type Ia (PHP Ia) is a hereditary endocrine disorder, characterised by resistance to parathyroid hormone (PTH), causing disturbance of calcium homeostasis, and to several other polypeptide hormones. Patients with PHP Ia exhibit a complex of somatic abnormalities, termed Albright hereditary osteodystrophy (AHO). Treatment with vitamin D derivatives alleviates symptoms of hypocalcemia and may prevent bone demineralisation. PTH, like many polypeptide hormones, exerts its… CONTINUE READING