Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone

@article{Bardin1970PseudohermaphroditeRE,
  title={Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone},
  author={C. Bardin and L. Bullock and G. Schneider and J. E. Allison and A. J. Stanley},
  journal={Science},
  year={1970},
  volume={167},
  pages={1136 - 1137}
}
The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone. 
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  • 68
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  • 142
  • Highly Influenced
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References

SHOWING 1-9 OF 9 REFERENCES
Sex Differences in Pentobarbital Sensitivity in Mice.∗
  • 26
The effect of anabolic steroids on drug metabolism by microsomal enzymes in rat liver.
  • J. Booth, J. Gillette
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1962
  • 63
Absence of response to dihydrotestosterone in the syndrome of testicular feminization.
  • 45
We thank A. French for technical assistance