Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice

@article{Hao2007PseudoginsenosideF11DM,
  title={Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice},
  author={Yue Hao and Jing Y Yang and Chun-Fu Wu and Min Fan Wu},
  journal={Pharmacology Biochemistry and Behavior},
  year={2007},
  volume={86},
  pages={660-666}
}
Morphine produces a variety of behavioral and biochemical changes related to its abuse. Our previous studies showed that Pseudoginsenoside-F11 (PF11), an ocotillol-type saponin existing in American ginseng, can antagonize pharmacological effects of morphine. To further investigate the effects of PF11 on morphine abuse and the underlying mechanisms, we tested the effects of PF11 on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial… 
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