Pseudogene evolution and natural selection for a compact genome.

@article{Petrov2000PseudogeneEA,
  title={Pseudogene evolution and natural selection for a compact genome.},
  author={Dmitri A. Petrov and Daniel L. Hartl},
  journal={The Journal of heredity},
  year={2000},
  volume={91 3},
  pages={221-7}
}
Pseudogenes are nonfunctional copies of protein-coding genes that are presumed to evolve without selective constraints on their coding function. They are of considerable utility in evolutionary genetics because, in the absence of selection, different types of mutations in pseudogenes should have equal probabilities of fixation. This theoretical inference justifies the estimation of patterns of spontaneous mutation from the analysis of patterns of substitutions in pseudogenes. Although it is… CONTINUE READING