Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

  title={Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes},
  author={Oliver H Tam and A. A. Aravin and Paula Stein and Ang{\'e}lique Girard and Elizabeth P. Murchison and Sihem Cheloufi and Emily Hodges and Martin Anger and Ravi Sachidanandam and Richard M Schultz and Gregory J Hannon},
Pseudogenes populate the mammalian genome as remnants of artefactual incorporation of coding messenger RNAs into transposon pathways. Here we show that a subset of pseudogenes generates endogenous small interfering RNAs (endo-siRNAs) in mouse oocytes. These endo-siRNAs are often processed from double-stranded RNAs formed by hybridization of spliced transcripts from protein-coding genes to antisense transcripts from homologous pseudogenes. An inverted repeat pseudogene can also generate abundant… CONTINUE READING
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