Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer

  title={Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer},
  author={Weiyang Lou and B. Ding and Pei-fen Fu},
  journal={Frontiers in Cell and Developmental Biology},
  • Weiyang Lou, B. Ding, Pei-fen Fu
  • Published 2020
  • Biology, Medicine
  • Frontiers in Cell and Developmental Biology
  • Pseudogenes, abundant in the human genome, are traditionally considered as non-functional “junk genes.” However, recent studies have revealed that pseudogenes act as key regulators at DNA, RNA or protein level in diverse human disorders (including cancer), among which pseudogene-derived long non-coding RNA (lncRNA) transcripts are extensively investigated and has been reported to be frequently dysregulated in various types of human cancer. Growing evidence demonstrates that pseudogene-derived… CONTINUE READING
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