Pseudoephedrine is without ergogenic effects during prolonged exercise.

@article{Gillies1996PseudoephedrineIW,
  title={Pseudoephedrine is without ergogenic effects during prolonged exercise.},
  author={Hunter Campbell Gillies and Wayne Derman and Timothy David Noakes and P Smith and Alicia Evans and Gary Gabriels},
  journal={Journal of applied physiology},
  year={1996},
  volume={81 6},
  pages={
          2611-7
        }
}
This study was designed to measure whether a single dose of 120 mg pseudoephedrine ingested 120 min before exercise influences performance during 1 h of high-intensity exercise. The effects of exercise on urinary excretion of the drug were also studied. Ten healthy male cyclists were tested on two occasions, separated by at least 7 days, by using a randomly assigned, double-blind, placebo-controlled, crossover design. Exercise performance was tested during a 40-km trial on a laboratory cycle… 

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Pseudoephedrine and preexercise feeding: influence on performance.

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References

SHOWING 1-10 OF 26 REFERENCES

The effects of ephedrine on the physiological and psychological responses to submaximal and maximal exercise in man.

Efforts to determine whether a single full therapeutic dose of ephedrine taken orally has any effect upon physical performance and fitness in healthy young men found it had no effect on lung function, but may have assisted the learning of certain simple psychomotor tasks.

Impaired high-intensity cycling performance time at low levels of dehydration.

Only the ratings of perceived exertion (RPE) and plasma anti diuretic hormone (ADH) concentrations were significantly increased in the NF trial compared to the F trial; however, weight loss was significantly reduced during F compared to NF.

Hormonal, electrolyte, and renal responses to exercise are intensity dependent.

Previous work indicates that the magnitude and direction of renal responses to exercise depend on the exercise intensity. To examine mechanisms responsible for these findings, renal and hormonal

Urinary excretion of chlorpheniramine and pseudoephedrine in humans.

In spite of expected changes in its biological half-life, the overall amount of unchanged pseudoephedrine excreted in urine was not affected by urine pH, presumably because it is primarily excreting in urine as intact drug.

Effects of acute hypoxia on renal and endocrine function at rest and during graded exercise in hydrated subjects.

Renal and hormonal function was investigated in eight males at rest and during graded exercise at sea level and 48 h after rapid ascent to 4,350 m, demonstrating that renal glomerular and tubular function is well preserved in acute hypoxia despite marked hormonal changes.

The Efficacy of Ergogenic Agents in Athletic Competition: Part II: Other Performance-Enhancing Agents

The literature describing the epidemiology, pharmacology, efficacy, and adverse effects associated with growth hormone, caffeine, aerobic metabolism facilitator (AMF), and sympathomimetic use among athletes is summarized.

Urinary Excretion of Ephedrine After Nasal Application in Healthy Volunteers

It is shown that the therapeutic use of a nasal ephedrine formulation by an athlete on the day of a competition can lead to a urinaryEphedrine concentration above 5 μg mL−1, which is considered positive in current doping regulations of the International Union of Cyclists.

Plasma volume and renal function during and after ultramarathon running.

There is a increase in creatinine clearance, indicating an increase in glomerular filtration rate, after both standard and ultramarathon running, which may be caused by the products of muscle cell damage although the physiologic mechanism for this is unclear.

Influence of Exercise on the Pharmacokinetics of Drugs

The chance of a clinically relevant effect of exercise on the pharmacokinetics of a particular drug is largest in those with a steep dose-response curve, a narrow therapeutic range, a need for continuity of therapeutic effectiveness and a relatively short half-life, in combination with intensive exercise of long duration.

Behavioral and neurochemical evaluation of phenylpropanolamine.

PPA is an effective anorectic in rhesus monkeys that, based upon drug discrimination results, would be expected to have limited amphetamine-like subjective effects and only at doses well in excess of effective anOREctic doses.