Pseudocounts for transcription factor binding sites

Abstract

To represent the sequence specificity of transcription factors, the position weight matrix (PWM) is widely used. In most cases, each element is defined as a log likelihood ratio of a base appearing at a certain position, which is estimated from a finite number of known binding sites. To avoid bias due to this small sample size, a certain numeric value… (More)
DOI: 10.1093/nar/gkn1019

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