Pseudobacteremia attributed to contamination of povidone-iodine with Pseudomonas cepacia.

  title={Pseudobacteremia attributed to contamination of povidone-iodine with Pseudomonas cepacia.},
  author={Ruth L. Berkelman and Sara Lewin and John R. Allen and R. L. Anderson and Lawrence D. Budnick and Samuel Shapiro and S M Friedman and Peter Nicholas and Robert S. Holzman and Robert W. Haley},
  journal={Annals of internal medicine},
  volume={95 1},
Pseudomonas cepacia was recovered from the blood cultures of 52 patients in four hospitals in New York over 6 months from April through October 1980. Epidemiologic investigation in one hospital indicated that the positive results of blood culture represented pseudobacteremias and implicated a 10% povidone-iodine solution used as an antiseptic and disinfectant (Pharmadine; Sherwood Pharmaceutical Company, Mahwah, New Jersey) as the source of contamination. Physicians who drew blood cultures… 

Infections and pseudoinfections due to povidone-iodine solution contaminated with Pseudomonas cepacia.

  • A. PanlilioC. Beck-Sague B. Hill
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1992
This investigation demonstrates that intrinsic contamination of povidone-iodine solution with P. cepacia can result in infections in addition to colonization and/or pseudoinfection.

Iodine—Champagne in a Tin Cup

  • M. Favero
  • Biology, Medicine
    Infection Control
  • 1982
Investigation of the recovery of Pseudomonas cepacia from blood cultures of 52 patients in four hospitals in New York City over a seven-month period from April through October 1980 found that the source of contamination was a commerciallyavailable 10% povidone-iodine (PI) solution used both as an antiseptic and as a disinfectant.

Burkholderia cepacia pseudobacteremia traced to contaminated antiseptic used for skin antisepsis prior to blood collection

An environmental and epidemiological investigation was carried out to identify the source and route of infection of B. cepacia, a problematic pulmonary pathogen in patients with cystic fibrosis that has the potential to cause fatal infections and its multidrug resistance makes its presence dangerous in hospital settings.

Klebsiella pneumoniae Pseudobacteremia Due to Cross-Contamination of A Radiometric Blood Culture Analyzer

Abstract Blood isolates from 13 patients in one hospital were positive for Klebsiella pneumoniae over a two-week period. Vials of potassium chloride used in intravenous fluid admixture initially were

Investigations of Intrinsic Pseudomonas cepacia Contamination in Commercially Manufactured Povidone-Iodine

The physical thickness of cellular and extracellular material that forms on surfaces could protect embedded organisms from the microbicidal action of disinfectants and antiseptics and subsequently allow for extended microbial survival times.

Nosocomial Burkholderia cepacia outbreaks and pseudo-outbreaks.

A strong association also has been found between B cepacia colonization and prior aminoglycoside therapy, thus reemphasizing the need to review guidelines for antimicrobial usage and prophylaxis in patients with cystic fibrosis.

Nosocomial Burkholderia cepacia Outbreaks and Pseudo-Outbreaks

A strong association also has been found between B cepacia colonization and prior aminoglycoside therapy, thus reemphasizing the need to review guidelines for antimicrobial usage and prophylaxis in patients with cystic fibrosis.

An Outbreak of Burkholderia cepacia Complex Associated with Intrinsically Contaminated Nasal Spray

Intrinsic contamination of Major Twice-A-Day 12-hour nasal spray with B. cepacia complex resulted in nosocomial transmission to 4 patients at the authors' facility and resulted in a voluntary product recall by the manufacturer.

Nosocomial outbreak of Pseudomonas cepacia respiratory infection in immunocompromised patients associated with contaminated nebulizer devices.

The results demonstrated that the outbreak of P. cepacia respiratory colonization in immunocompromised patients was a nosocomial acquisition, and probably occurred by transmission through contaminated nebulizer devices.

Prolonged survival of Pseudomonas cepacia in commercially manufactured povidone-iodine

Current laboratory data and lot production date information from the manufacturer indicate that P. cepacia survived for up to 68 weeks from the time of manufacture.



Pseudomonas cepacia septicemia associated with intravenous therapy.

Four cases of Pseudomonas cepacia septicemia were found in one hospital in 1971. Two were related to severe phlebitis of the arms due to intravenous catheters, a third to an infected central venous

Colonization and infection with Pseudomonas cepacia.

These strains were consistently susceptible only to the sulfonamides, chloramphenicol, and naladixic acid and were routinely resistant to gentamicin and the polymyxins.

Absence of bacterial resistance to povidone iodine.

No significant change was observed in the minimal inhibitory concentration, minimal bactericidal concentration, and killing times between parent strains and 20th subcultures under standardized conditions after 20 passages of Povidone iodine.

Sources of the slow-growing pigmented water bacteria.

Although present at low levels in free-flowing domestic water supplies, several strains have been implicated in infections in nurseries and among patients in intensive care units and the use of bacteria-free water whenever possible.

Factors influencing the occurrence of high numbers of iodine-resistant bacteria in iodinated swimming pools.

Comparing the microbial flora of four alternately chlorinated and iodinated swimming pools showed that, although viable counts were significantly higher during the iodinated periods, the specific types of bacteria determined were either fewer than or the same as in chlorinated periods.

Drug resistance studies with topical antiseptics.

Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to

Antibiotic susceptibility testing by a standardized single disk method.

Recommendations of the National Committee for Clinical Laboratory Standards continue to be based on this publication; the “Kirby-Bauer” method is, among the many disk methods used in other countries, still the one that has been researched most thoroughly and updated continuously.