Pseudo-thermosetting chitosan hydrogels for biomedical application.

  title={Pseudo-thermosetting chitosan hydrogels for biomedical application.},
  author={J{\'e}r{\^o}me Berger and Marianne Reist and Abdellatif Chenite and Olivia Felt-Baeyens and Joachim Michael Mayer and Robert Gurny},
  journal={International journal of pharmaceutics},
  volume={288 1},
To prepare transparent chitosan/beta-glycerophosphate (betaGP) pseudo-thermosetting hydrogels, the deacetylation degree (DD) of chitosan has been modified by reacetylation with acetic anhydride. Two methods (I and II) of reacetylation have been compared and have shown that the use of previously filtered chitosan, dilution of acetic anhydride and reduction of temperature in method II improves efficiency and reproducibility. Chitosans with DD ranging from 35.0 to 83.2% have been prepared… CONTINUE READING