Pseudo-gamma heavy chain (IgG4 lambda) deposition disease.

  title={Pseudo-gamma heavy chain (IgG4 lambda) deposition disease.},
  author={Raymond R. Tubbs and V. Berkley and Rolando Valenzuela and J T. Mcmahon and Gordon N. Gephardt and A. Fishleder and Joseph V. Nally and Marc A. Pohl and Ronald M. Bukowski and Alan Eli Lichtin},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  volume={5 2},
Two patients with Ig deposition disease presented with acute renal failure, moderate proteinuria, and hematuria. A plasmacytoid lymphocytic infiltrate was identified in bone marrow that produced IgG4 lambda and free lambda light chains. One patient developed an anaplastic plasmacytoma (secreting only lambda light chains) 1 yr after renal biopsy. Renal biopsy in both patients demonstrated a nodular intercapillary glomerulopathy and electron dense granular deposits, associated with a linear… CONTINUE READING