Pseudo-constitutivity of nitrate-responsive genes in nitrate reductase mutants

  title={Pseudo-constitutivity of nitrate-responsive genes in nitrate reductase mutants},
  author={Thorsten Schinko and Andreas Gallmetzer and Sotiris Amillis and Joseph Strauss},
  booktitle={Fungal genetics and biology : FG & B},
In fungi, transcriptional activation of genes involved in NO3(-) assimilation requires the presence of an inducer (nitrate or nitrite) and low intracellular concentrations of the pathway products ammonium or glutamine. In Aspergillus nidulans, the two transcription factors NirA and AreA act synergistically to mediate nitrate/nitrite induction and nitrogen metabolite derepression, respectively. In all studied fungi and in plants, mutants lacking nitrate reductase (NR) activity express nitrate… CONTINUE READING
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