Pseudo–Messenger RNA: Phantoms of the Transcriptome

  title={Pseudo–Messenger RNA: Phantoms of the Transcriptome},
  author={Martin C. Frith and Laurens G. Wilming and Alistair R. R. Forrest and Hideya Kawaji and Sin Lam Tan and Claes Wahlestedt and Vladimir B. Bajic and Chikatoshi Kai and Jun Kawai and Piero Carninci and Yoshihide Hayashizaki and Timothy L. Bailey and Lukasz Huminiecki},
  journal={PLoS Genetics},
  pages={1149 - 1154}
The mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to be RNA molecules that resemble protein-coding mRNA, but cannot encode full-length proteins owing to disruptions of the reading frame. Using a rigorous computational pipeline, which rules out sequencing errors, we identify 10,679 pseudo-messenger RNAs (approximately half of which are transposon-associated) among the 102,801 FANTOM3 mouse… CONTINUE READING
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