Pseudellones A-C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3.

Abstract

Pseudellones A and B (1 and 2), a pair of irregularly bridged epimonothiodiketopiperazine diastereomers constructed from unusual 3-indolylglycine and alanine residues, and an alkaloid pseudellone C (3) possessing a unique skeleton were isolated from the marine-derived fungus Pseudallescheria ellipsoidea F42-3. Their structures were determined by spectroscopic data, ECD calculation, and X-ray single crystal diffraction. The biogenetic pathways of 1-3 were proposed, and 1H-indole-3-carboxylic acid (4), a plausible biosynthetic intermediate, was coisolated.

DOI: 10.1021/acs.orglett.5b02311

Cite this paper

@article{Liu2015PseudellonesAT, title={Pseudellones A-C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3.}, author={Wei Liu and H Li and Meng-Yang Xu and Ying-Chen Ju and Lai-you Wang and Jun Xu and De-Po Yang and Wen-Jian Lan}, journal={Organic letters}, year={2015}, volume={17 21}, pages={5156-9} }