Psammoma bodies and abundant stromal amyloid in an endoscopic ultrasound guided fine needle aspirate (EUS‐FNA) of a pancreatic neuroendocrine tumor: A potential pitfall

@article{Samad2014PsammomaBA,
  title={Psammoma bodies and abundant stromal amyloid in an endoscopic ultrasound guided fine needle aspirate (EUS‐FNA) of a pancreatic neuroendocrine tumor: A potential pitfall},
  author={Arbaz Samad and Rajeev Attam and Jose Jessurun and Stefan E. Pambuccian},
  journal={Diagnostic Cytopathology},
  year={2014},
  volume={42}
}
A 42-year-old male presented to our institution with a 2-month history of several episodes of confusion, double vision, headache, and loss of consciousness. The blood glucose levels measured during these episodes were in the range of 30–40 mg/dl, but randomly drawn blood samples showed normal glucose levels. Further workup showed a fasting blood glucose level of 34 mg/dl at 60 hours and elevated proinsulin levels, while insulin and C-peptide levels were normal. Serum levels of chromogranin A… 
4 Citations
Amyloid-Rich Pancreatic Neuroendocrine Tumors: a Potential Diagnostic Pitfall in Endoscopic Ultrasound–Guided Fine Needle Aspiration Cytology (EUS-FNAC)
TLDR
The diagnostic clues of the amyloid-rich variant of PanNETs in endoscopic ultrasound–guided fine needle aspiration cytology (EUS-FNAC) are described and the neuroendocrine nature was confirmed by immunoexpression of synaptophysin and chromogranin A, while the amorphous stroma was characterized as amyloids based on positive Congo red staining.
Amyloid in endobronchial ultrasound‐guided transbronchial needle aspiration cytology
TLDR
The FNA was diagnosed as tumoral amyloidosis (“amyloidoma”) with lambda light chain overexpression with a note that the most likely etiologies were plasma cell dyscrasia and lymphoplasmacytic lymphoma and that further work-up was recommended.
Colonic Angiosarcoma Arising in Association with Amyloid Deposits
TLDR
A case of 77-year-old man who presented with hematochezia, and a sigmoid mass was found on colonoscopy is described, and it is hypothesize that angiosarcoma could be secondary to amyloid deposition.
INSM1, a Novel Biomarker for Detection of Neuroendocrine Neoplasms: Cytopathologists’ View
TLDR
This review summarizes existing literature on INSM1′s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).

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