Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase.

@article{Pia2003PsammaplinsFT,
  title={Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase.},
  author={Ivette C Pi{\~n}a and Jeffrey T Gautschi and Gui-Yang-Sheng Wang and Miranda L. Sanders and Francis J. Schmitz and Dennis France and Susan A. Cornell-Kennon and Lidia C Sambucetti and Stacy W Remiszewski and Larry B Perez and Kenneth W. Bair and Phillip Crews},
  journal={The Journal of organic chemistry},
  year={2003},
  volume={68 10},
  pages={3866-73}
}
Four novel bisulfide bromotyrosine derivatives, psammaplins E (9), F (10), G (11), and H (12), and two new bromotyrosine derivatives, psammaplins I (13) and J (14), were isolated from the sponge Pseudoceratina purpurea, along with known psammaplins A (4), B (6), C (7), and D (8) and bisaprasin (5). The structures of psammaplins E (9) and F (10), which each contain an oxalyl group rarely found in marine organisms, were determined by spectroscopic analysis. Compounds 4, 5, and 10 are potent… CONTINUE READING

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