Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.

@article{Kim2015PsammaplinAI,
  title={Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.},
  author={Tae Hyung Kim and Hyuk Soon Kim and Yoon Jong Kang and Sungpil Yoon and Jaewon Lee and Wahn Soo Choi and Jee H Jung and Hyung Sik Kim},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1850 2},
  pages={401-10}
}
BACKGROUND Psammaplin A (PsA) is a natural product isolated from marine sponges, which has been demonstrated to have anticancer activity against several human cancer cell lines via the induction of cell cycle arrest and apoptosis. New drugs that are less toxic and more effective against multidrug-resistant cancers are urgently needed. METHODS We tested cell proliferation, cell cycle progression and autophagic cell death pathway in doxorubicin-resistant MCF-7 (MCF-7/adr) human breast cancer… CONTINUE READING
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